Vhb Life Sciences Limited Mumbai, Maharashtra

Injection

Bleomycin Injection

Bleomycin Injection

Generic
BLEOMYCIN

Classification
Antitumor antibiotic

Mechanism of action
Bleomycin causes single and double strand DNA break through formation of an intermediate iron complex. DNA synthesis, and to lesser degree, RNA and protein synthesis are inhibited. Bleomycin is cell cycle phase-specific.

Composition
Each vial contains
Bleomycin Sulphate I.P.
equivalent to Bleomycin.................. 15 units

Injection

Storage
Store at 2-8C (Refrigerate. Do not freeze) and shelf life is 36 months.

Strength

Dacarbazine Injection

Dacarbazine Injection

ZOL Generic:
Dacarbazine

Classification:
Alkylating agent

Composition:
Oncodac 100mg
Each vial contains dacrbazine Usp………100mg
Citric acid i. P. ……. . Q. S.
Mannitol i. P. Q. S.

Oncodac 200 mg
Each vial contains dacrbazine Usp………200mg
Citric acid i. P. ……. . Q. S.
Mannitol i. P. Q. S.

oncodac 500 mg
each vial contains dacrbazine usp………500mg
citric acid i. P. ……. . Q. S.
mannitol i. P. Q. S.

mechanism of action:
dacarbazine is a structural analogue of imidazole carboxamide, a purine precursor. Dacarbazine undergoes activation via cytochrome p450 in the liver to the reactive compound, methyltriazenoimidazole carboxamide (mtic). The cytotoxicity of mtic is thought to be due primarily to the formation of methylcarbonium ions that attack nucleophilic groups in dna. Dacarbazine may also inhibit dna and rna synthesis by acting as a purine analogue and by interacting with sulfhydryl groups. Dacarbazine is cell cycle phase-nonspecific and is mildly immuno-suppressive

Indications:

Storage:

Strengths:

Soloxan Ifosfamide Injections

Soloxan Ifosfamide Injections

generic:
ifosfamide

classification:
alkylating agent

mechanism of action:
its mode of action consists of interference with dna action by reaction with phosphodiester bridges thus preventing the cell division. It is considered to be cell cycle non-specific.

composition:
each vial contains
soloxan 500 mg combipack
ifosfamide usp…. . 500 mg

each vial contains
soloxan 1g combipack
ifosfamide usp…. . 1g

each vial contains
soloxan 2g combipack
ifosfamide usp…. . 2g

indication:

storage:

Procarb

Procarb
Generic: 
procarbazine

classification: 
alkylating agent

composition:
each capsules contains 50mg of procarbazineas procarbazine hydrochloride

mechanism of action:
it inhibits incorporation of small dna precursors, as well as rna and protein synthesis. Procarbazine can also directly damage dna through an alkylation reaction. Procarbazine is not cross-resistant with other alkylating agents and is cell cycle phase-specific (s-phase). 

indications: 


storage:
tight, light-resistant containers at 15-30ºc (may be exposed to =40ºc). 

strengths:

Cybin Pf Injection 100mg/ml

Cybin Pf Injection 100mg/ml
Generic: 
CYTARABINE, CYTOSINE ARABINOSIDE (Ara-C)

Classification: 
Antimetabolite

Composition:
Each ml contains Cytrabine ………….100mg.

Mechanism of action:
Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzyme needed for the DNA synthesis. Cytarabine is rapidly deaminated in the body into the inactive uracil derivative form and therefore, it is often given by continuous intravenous infusion.

Indication: 

Storage: 

Cybin Pf Inj 100mg/ml

Cybin Pf Inj 100mg/ml
GENERIC: 
CYTARABINE, CYTOSINE ARABINOSIDE (Ara-C)

CLASSIFICATION: 
Antimetabolite

COMPOSITION:
Each ml contains Cytrabine ………….100mg.

MECHANISM OF ACTION:
Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzyme needed for the DNA synthesis. Cytarabine is rapidly deaminated in the body into the inactive uracil derivative form and therefore, it is often given by continuous intravenous infusion.

INDICATION: 

STORAGE: 
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    (IT Manager)

    Vhb Life Sciences Limited

    Kandivali, Mumbai, Maharashtra, India

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