Vhb Life Sciences Limited Mumbai, Maharashtra

Antibiotic Inj n Oral

Eside 50mg 1 X 8caps

Eside 50mg 1 X 8caps
Generic Name : Inj.Etoposide 

Indication : 
NSCLC, Testicular malignancy, Acute Myeloid Leukemia 

Our Brand Name : 
ESIDE

Methotrexate

Generic: 
methotrexate

Classification: 
Antimetabolite

Mechanism of action: 
Cell cycle-specific antifolate analog, active in s-phase of the cell cycle. Enters cells through specific transport systems mediated by the reduced folate carrier and the folate receptor protein. Inhibition of dihydrofolate reductase (dhfr) resulting in depletion of critical reduced folates. Inhibition of de novo thymidylate synthesis. 

Composition
Hitrex injection - 15mg/3ml
each ml contains methotrexate u. S. P. . . . . . 5mg
water for injection u. S. P.  . Q. S. 
hitrex 50mg/2ml
each ml contains methotrexate u. S. P. . . . . . . 25mg
water for injection u. S. P. . . . Q. S. 
hitrex 500mg/5ml
each ml contains methotrexate u. S. P. . . 100mg
water for injection u. S. P.  .

Indication: 
Breast cancer. 
Head and neck cancer. 
Osteogenic sarcoma. 
Acute lymphoblastic leukemia. 
Non-hodgkin's lymphoma. 
Meningeal leukemia
Bladder cancer. 
Colorectal cancer

Storage:
Store vials between 36° and 77°f in Original package to protect from Bright light. 

Strengths: 
2. 5 mg tab, 15 mg inj. & 50mg inj.

Eside 100mg/5ml Vial

Generic Name : Inj.Etoposide 

Indication : 
NSCLC,Testicular malignancy, Acute Myeloid Leukemia 

Our Brand Name : 
ESIDE

Gemlife - rd 200mg

Generic Name : Inj. Rapd Disolution Gemcitabine 

Indication : 
CBreast cancer,Ovarian cancer, Non small cell lung cancer (NSCLC),Pancreatic cancer 

Our Brand Name : 
GEMLIFE-RD

STRENGTHS:

Bleosol

GENERIC: 
BLEOMYCIN

CLASSIFICATION: 
Antitumor antibiotic

MECHANISM OF ACTION:
Bleomycin causes single and double strand DNA break through formation of an intermediate iron complex. DNA synthesis, and to lesser degree, RNA and protein synthesis are inhibited. Bleomycin is cell cycle phase-specific.

COMPOSITION
Each vial contains: 
Bleomycin Sulphate I.P.
equivalent to Bleomycin.................. 15 units

INDICATIONS: 

STORAGE:
Store at 2-8ºC (Refrigerate. Do not freeze) and shelf life is 36 months. 

STRENGTHS:

Epicin-RD 10mg lyp. Vial

Generic Name : Inj. Rapd Disolution Epirubicin 

Indication : 
Metastatic Breast cancer,gastric cancer,Hodgkin's and Non Hodgkin's Lymphoma 

Our Brand Name : 
EPICIN-RD

STRENGTHS:

Neotaxl 100mg/16.7ml Vial

Generic Name : Inj.Paclitaxel 

Indication : 
Breast cancer, Ovarian cancer, Lung cancer, Head& Neck cancer 

Our Brand Name : 
NEOTAXL

STRENGTHS:

Adrosal 10MG lyp. Vial

Generic Name : Inj. Doxorubicin Hydrochloride 

Indication : 
Breast cancer,Gastric cancer,H&N cancer,Leukemia,Lymphoma 

Our Brand Name : 
ADROSAL

STRENGTHS:

Adronex Dronex RD 10 mg (COMBIPACK)

Generic Name : Inj. Rapd Disolution Doxorubicin Hydrochloride 

Indication : 
Breast cancer,Gastric cancer,H&N cancer,Leukemia,Lymphoma 

Our Brand Name : 
ADRONEX RD

STRENGTHS:

Platifirst

Generic: Cisplatin

Classification: 
Alkylating like agents, miscellaneous agent

Composition:
Platifirst injection bp 10mg/10ml
each ml contains:
cisplatini. P. ………. 10mg

Platifirst injection bp 50mg/50ml
Each ml Contains:
cisplatini. P. ………. 50mg

Mechanism of action: 
Cisplatin is similar to the bifunctional alkylating agents. It covalently binds to dna and disrupts dna function. After cisplatin enters the cells, the chloride ligands are replaced by water molecules. This reaction results in the formation of positively charged platinum complexes that react with the nucleophilic sites on dna. These platinum complexes covalently bind to dna bases using intra-strand and inter-strand cross-links creating cisplatin-dna adducts thus preventing dna, rna and protein synthesis. This action is cell cycle phase-nonspecific. Cisplatin has immunosuppressive, radiosensitizing, & antimicrobial properties. 

indication:

Strengths:

storage:
cisplatin is available as sterile, unpreserved; single-dose vials (10 mg/10 ml & 50 mg/50 ml. Unopened vials are stored at room temperature. Do not refrigerate or freeze cisplatin solutions, as a precipitate will form. Protect from light.

Ivin Injection

Generic: 
Vincristine

Classification:
Mitotic Inhibitor

Mechanism of Action: 
Vincristine prevents the formation of spindle fibers during metaphase of mitosis. It binds to tubulin, the protein that makes up the spindle fiber microtubules, and prevents metaphase of mitosis. 

Composition:
Each ml contains:
Vincristine sulphate i. P. ……. 1 mg
Mannitol i. P. …………100mg
Methyl paraben i. P……13% v/v
Propyl paraben i. P……. 0. 02% v/v

Indications: 

Storage:
This product should be refrigerated between 2°- 8° c (36°- 46° f)

Strengths:

Daunoplus 20mg (COMBIPACK)

Generic: 
Daunarubicin

Classification: 
antitumor antibiotic

Composition: 
Each vial contains:
Daunorubicin hydrochloride usp 
equivalent to daunorubicin ………. 20mg

Mechanism of action:
Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: daunorubicin forms complexes with dna by intercalation between base pairs, and it inhibits topoisomerase ii activity by stabilizing the dna-topoisomerase ii complex, preventing the religation portion of the ligation-religation reaction that topoisomerase ii catalyzes.

Indications: 

Storage:
Store unopened vials in refrigerator, 2° to 8°c (36° to 46°f). Store prepared solution for infusion at room temperature, 15° to 30°c (59° to 86°f) for up to 24 hours. Contains no preservative. Discard unused portion. Protect from light.  

strengths:

Amfos 500mg Lyp. Vial

Generic: 
amifostine

classification:
chemo-radio protectant

composition: 
each vial contains:
amifostine usp eqvivalent to 
amifostine anhydrous ……500mg

mechanism of action:
amifostine is a pro-drug, which is activated to the free thiol metabolite at the tissue site. The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells. 

indications: 

storage: 
parenteral
powder for injection
20-25ºc. Reconstituted solution is stable for 5 hours at room temperature (approximately 25ºc) or 24 hours under refrigeration (2-8ºc). 

strengths:

L- Asparaginase

Generic: 
L- ASPARAGINASE

Classification:
Antitumour antibiotic, cytotoxic

Mechanism of Action: 
Asparaginase hydrolyzes the amino acid L-asparagine to L-aspartic acid and ammonia. Asparagine is required for DNA synthesis and cell survival; however, most cells are capable of synthesizing asparagine from glutamine. Acute lymphoblastic leukemia (ALL) cells lack adequate levels of the required enzyme, asparagine synthetase, and cannot survive asparagine depletion. Asparaginase is cycle-specific for the G1 phase.

Composition: 
Each Vial Contains 
L-asparginase ……5000 I.U.
Glycine……….q.s.

Each vial contains]
L-asparginase ……10000 I.U.
Glycine……….q.s.

Indication: 

Strength:

Storage: 

Epirubicin 10 Mg/10ml

Generic: 
EPIRUBICIN

Classification: 
Antitumour antibiotic

Mechanism of action:
It intercalates into DNA, which results in inhibition of DNA synthesis and function. It inhibits Topoisomerase II by forming a cleavable complex with Topoisomerase II and DNA. It is also involved in oxidation/reduction reactions by generating cytotoxic oxygen free radicals, which can cause single & double-stranded DNA breaks.

Composition:
Each vial contains:Epicin 10mg
Epirubicin Hydrochloride B.P.……..10mg
Methyl Paraben I.P…..2mg
Lactose I.P. ……..q.s.
Each vial contains: Epicin 50mg
Epirubicin Hydrochloride B.P.……..50mg
Methyl Paraben I.P…..20mg
Lactose I.P. ……..q.s.

Indication: 
Epirubicin is recommended for the treatment of metastatic breast cancer. Epirubicin may also be used as a component in the adjuvant treatment of early stage breast cancer for pre- and peri- menopausal women.

Dacmozen

generic: 
dactinomycin, actinomycin

classification:
antitumor antibiotic

composition:
each vial contains
dactinomycin……. . 5mg

mechanism of action: 
it is belived to produce its cytotoxic affects by binding dna & inhibiting rna synthesis. It also causes intercalation preferentially with guanine base pairs. Thus act as a potent inhibitor of rna. 

indications: 

strength: 

storage:

Adrosal 10 Mg Lyophilised Vial

Generic:
Doxorubicin

Classification:
Antitumour Antibiotic

Composition:
Each Vial Contains:
Doxorubicin Hydrochloride…10mg
Lactose ……q.s.

Mechanism Of Action:
Doxorubicin Damages Dna By Intercalation Of The Anthracycline Portion, Metal Ion Chelation, Or By Generation Of Free Radicals. Doxorubicin Has Also Been Shown To Inhibit Dna Topoisomerase Ii That Is Critical To Dna Function. Cytotoxic Activity Is Cell Cycle Phase-nonspecific.

Indication:

Storage:

Tiecaaz 200mg ( Combipack)

Tiecaaz 200mg ( Combipack)
Tarabin 80mg/2ml vial.

Ivipime Antibiotic Drug

We are manufacture

Aztre 1gm (combipack)

we are manufacture

Aztre ( 4 Strength Missing)

we are manufacture
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Reselling End Use Raw Material

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    Ketan Bavishi

    (IT Manager)

    Vhb Life Sciences Limited

    Kandivali, Mumbai, Maharashtra, India

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